Homocysteine Factors

Vitamin B12 and folate are required by the enzyme that converts homocysteine back to methionine. Folate is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate.

Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations.

Vitamin B6 is required in each of the two enzymatic reactions that convert homocysteine to cysteine. One of the major roles of betaine, also known as trimethylglycine, is in promoting healthy homocysteine metabolism. It is believed that betaine may be especially supportive when vitamin B12, folic acid and vitamin B6 are not sufficient to maintain healthy homocysteine levels.

Vitamin B12 is derived from microbiological fermentation. Vitamin B6 and folic acid (Metafolin®, L-5- MTHF) are synthetically produced. Betaine is originally derived from sugar beet molasses and undergoes an extensive purification process. Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and hypoallergenic plant fiber is derived from pine cellulose.