In 1922, a patient spoke to Nurse Rene M. Caisse of a Canadian Ojibwa Indian herbal formula. Nurse Caisse prepared her original herbal formula into a drink named Essiac, which is Nurse Caisse's name spelled backwards. From 1922 to 1978 Nurse Rene Caisse lived in Bracebridge, Ontario, Canada. She ran her clinic on Dominion Street from 1934 to 1942 and continued to give Essiac to people until the late 1970's. When people came to see her she instructed them to “cross the silver bridge and turn left”. Although she refused payments for her services, she accepted donations to help support her clinic.
In 1977, Nurse Caisse signed over all her rights to her original Essiac formula only to Resperin Corporation Limited. Dr. Charles Brusch of Cambridge, MA, witnessed the signing of the agreement between Rene Caisse and Resperin attesting that her original herbal formula was never revealed to anyone other than to Resperin. Rene Caisse continues to be loved and remembered for her contributions to naturopathic medicine. Bronze sculptures of Nurse Caisse have been dedicated in Bracebridge and at the Canadian College of naturopathic Medicine in Toronto.