Bio-Flex III

Bio-Flex III Broad Spectrum Formula

Bio-Flex III is a comprehensive joint-support formula designed to promote comfort, flexibility, and healthy mobility with a targeted blend of glucosamine sulfate, chondroitin sulfate, curcumin, Boswellia, vitamin C, manganese, and BioPerine®.* It was developed to emphasize ingredients and standardizations with the strongest human clinical rationale for supporting joint function, especially in adults experiencing age-related joint stiffness, occasional discomfort, or reduced ease of movement. Its updated design focuses on more clinically meaningful amounts of key ingredients and a more targeted botanical strategy than the previous Bio-Flex II formula.

Ingredient Highlights

Glucosamine Sulfate (2000 mg)

Glucosamine sulfate is included to support cartilage structure and long-term joint integrity. In a 2024 systematic review and meta-analysis of randomized trials, glucosamine sulfate showed a significant benefit for reducing tibiofemoral joint-space narrowing, supporting its role in preserving joint structure over time.*

Chondroitin Sulfate (1000 mg)

Chondroitin sulfate is one of the most clinically relevant ingredients in the formula for joint comfort and physical function. Human trials and meta-analytic data show that chondroitin sulfate can help reduce pain, improve physical function, and support the resilience and hydration of cartilage. In a large controlled trial, 800 mg/day pharmaceutical-grade chondroitin sulfate was superior to placebo and similar to celecoxib for improving pain and function over 6 months in symptomatic knee osteoarthritis.*

Curcumin Extract (95% Curcuminoids) (1000 mg)

Curcumin is a leading botanical ingredient for joint comfort, stiffness, and mobility. A 2024 Bayesian network meta-analysis of 23 randomized controlled trials involving 2,175 patients found that curcumin significantly improved pain and WOMAC scores versus placebo, and a multicenter human trial in 367 patients found Curcuma domestica extract comparable to ibuprofen for pain and function with fewer gastrointestinal complaints.*

Boswellia serrata Extract (30% AKBA) (100 mg)

Boswellia in Bio-Flex III is standardized to 30% AKBA, the boswellic-acid fraction most directly linked to human osteoarthritis research. In a double-blind, randomized, placebo-controlled trial, a 30% AKBA Boswellia extract (5-Loxin®) significantly improved pain and physical function in adults with knee osteoarthritis and also reduced MMP-3, an enzyme associated with cartilage breakdown.*

Vitamin C (Ascorbate Complex) (260 mg)

Vitamin C provides foundational support for joint tissues because it is required for collagen biosynthesis and functions as an important physiological antioxidant. Since collagen is a major structural component of connective tissue, vitamin C helps support the integrity of cartilage, ligaments, tendons, and other joint-supporting tissues.*

Manganese (as manganese glycinate) (2 mg)

Manganese is a trace mineral that contributes to bone formation, antioxidant defense, and connective tissue support. The NIH Office of Dietary Supplements notes that manganese is a cofactor for enzymes involved in bone formation and reactive oxygen species scavenging, making it a supportive nutrient for healthy musculoskeletal aging.*

BioPerine® (Piperine) (4 mg)

BioPerine® is included to support the bioavailability of curcumin. Piperine has been shown in human pharmacokinetic research to increase curcumin exposure, which is why Bio-Flex III pairs a meaningful curcumin dose with a recognized absorption-support ingredient.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.