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Supports the methylation pathway and seratonin levels.

TMG 500 mg w/Folate & Methyl B-12 is a hypoallergenic TMG supplement providing 500 mg trimethylglycine in a single plant-cellulose capsule plus 100 percent daily value of both folinic acid and vitamin B-12 for optimal TMG assimilation.

TMG, dimethylglycine with one more methyl group, is considered a methyl donor or methyl bank like DMG but may be a more active methyl donor due to its additional methyl group. TMG can support formation of methionine by methylating homocysteine. Some of this methionine is converted into SAMe (S-adenosylmethionine), which may help support normal serotonin levels for a balanced mood.

Sufficient amounts of folate are required for TMG to work properly in the body; that's why this TMG supplement includes 100 percent of your daily value of this important B vitamin in its most bioavailable form, folinic acid. And for additional support, and because low levels of vitamin B-12 may be masked by folic acid intake, each capsule also contains 100 percent of your daily value of B-12 in the bioavailable form methylcobalamin.

Ideal for individuals with allergies or sensitivities, this hypoallergenic supplement comes in plant-cellulose capsules and is free of GMOs, sugar, starch, soy, wheat, casein, gluten, milk, corn, egg, preservatives, yeast, gelatin, flavoring and colorings, peanuts, tree nuts, fish, shellfish.

Suggested Usage

1–2 capsules per day or as directed by a physician.


  • Serving Size: 1 Capsule
  • Servings Per Container: 120
  • Amount Per Serving:
  • Folate (as Calcium Folinate) 666 mcg DFE
  • Vitamin B-12 (as Methylcobalamin) 6 mcg
  • Trimethylglycine (as Glycinate Betaine) 500 mg

Other Ingredients: Dicalcium phosphate, vegetarian capsule (hypromellose and water), magnesium stearate

FREE OF: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy.


If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

Additional Information

Store in a cool, dry place tightly capped.

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