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With Metafolin® L-5-MTHF - Supports healthy fat metabolism, liver function, and detoxification.

The lipotropic agents in this formula: choline, betaine, methionine, vitamin B6, vitamin B12 and folic acid (Metafolin® L-5-MTHF), support healthy hepatic fat metabolism and bile flow. Efficient processing and breakdown of fats in the liver maintain healthy overall liver function and detoxification. These nutritional factors are also highly recognized for their ability to maintain healthy homocysteine metabolism. Taurine, curcumin, silymarin and artichoke support healthy bile flow, gene expression and the body’s normal toxin metabolism.

As methyl donors, choline, betaine, methionine, vitamin B6, vitamin B12 and folate (Metafolin® L-5-MTHF) are critical for methylation, a widespread biochemical process in the body that involves transferring a methyl group to another compound. Methylation of DNA supports healthy DNA integrity and stability, important for liver, colon and overall cell health.

Folate is provided in this formula as Metafolin®, the naturally occurring universally metabolized form of folate. Metafolin® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations.

Suggested Usage

As a dietary supplement, take 2 capsules 3 times daily with meals.


  • Serving Size: 2 Capsules
  • Servings Per Container: 60
  • Amount Per Serving:
  • Vitamin B6 (as pyridoxine HCl) 5 mg
  • Folate (as Metafolin®, L-5-MTHF) (100 mcg L-5-MTHF) 167 mcg
  • Vitamin B12 (as methylcobalamin) 50 mcg
  • Choline (as choline bitartrate) 120 mg
  • Inositol 150 mg
  • L-methionine (free-form) 150 mg
  • Taurine (free-form) 100 mg
  • Trimethylglycine (anhydrous betaine) 100 mg
  • Turmeric (Curcuma longa) extract (root) 75 mg
  • -standardized to contain 95% curcuminoids.
  • Milk thistle (Silybum marianum) extract (seed) 75 mg
  • -standardized to contain 80% silymarin.
  • Artichoke (Cynara scolymus L.) extract (leaf) 50 mg

Other Ingredients: hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water), ascorbyl palmitate.

Gluten-free, Non-GMO and Hypoallergenic.


If you are pregnant, nursing, trying to conceive, taking any medications, planning a medical procedure or have a medical condition, please consult your healthcare practitioner before using this product.

Trimethylglycine and turmeric can cause GI upset, including nausea or diarrhea. Artichoke and curcumin should be used with caution in patients with bile duct obstruction. Artichoke and milk thistle should be avoided by individuals with allergies to members of the aster (Asteraceae/Compositae) family.

Turmeric may be contra-indicated with blood thinning medications. Consult your physician for more information.

Keep out of reach of children.

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