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5-HTP Plus Formula capsules may be a useful nutritional supplement for individuals wishing to obtain the benefits of this well-documented plant extract to increase their levels of brain serotonin.
5-HTP Plus Formula capsules, provided by Douglas Laboratories, contain 75 mg of natural L-5-hydroxytryptophan (5-HTP) extracted from seeds of the Griffonia plant, together with 7.5 mg of pyridoxal-5-phosphate and 50 mg of a proprietary blend of the neurotransmitters L-tyrosine and L-glutamine. This product has been certified to be free of a contaminant, peak "x", implicated in a past incidence of dietary tryptophan-associated eosinophilia myalgia syndrome (EMS).
Serotonin, an important brain neurotransmitter, is key in the regulation of appetite, mood, and melatonin production. The presence of serotonin in the brain is associated with a balanced emotional state. This is achieved in part by decreasing the activity of certain excitatory hormones, including dopamine and noradrenaline. Serotonin also acts as a satiety signal in the brain, thereby naturally regulating food intake. Additionally, as a precursor of melatonin, serotonin is involved in regulating sleep patterns. Serotonin is unable to cross the blood-brain barrier and is therefore synthesized in the brain. Tryptophan, an essential amino acid, is a precursor for the synthesis of serotonin. Tryptophan crosses the blood-brain barrier and is converted to L- 5-hydroxytryptophan, which in turn is converted into serotonin. Unfortunately, tryptophan faces many obstacles during its journey into brain tissue. First, dietary intake directly affects body levels of tryptophan, as the body can not endogenously produce it. High protein diets often provide greater amounts of tryptophan, yet higher carbohydrate diets appear to enhance tryptophan uptake into the brain. Secondly, tryptophan must compete with other amino acids for entry into the brain. Finally, tryptophan may be taken up by other tissues for protein or niacin synthesis, and thus is not exclusively for use by the brain. As a metabolic intermediate in the conversion of tryptophan into serotonin, 5-HTP can also serve as a precursor of serotonin. 5-HTP offers a number of advantages over tryptophan. 5-HTP is derived naturally from the seeds of the Griffonia plant, unlike tryptophan which is produced synthetically or through bacterial fermentation. 5-HTP crosses into the brain more readily than tryptophan as it is able to cross the blood-brain barrier without competition for uptake. 5-HTP is significantly more effective than tryptophan; one 50 mg capsule of 5-HTP is roughly equivalent to 500 mg of tryptophan.
As a dietary supplement, adults take 1 capsule daily or as directed by your healthcare professional.
- Serving Size: 1 capsule
- Servings Per Container: 60
- Amount Per Serving:
- L-5-HTP (L-5-hydroxytryptophan) 75 mg
- Pyridoxal-5-Phosphate (P-5-P) 7.5 mg
- Proprietary Blend 50 mg
Other ingredients: Microcrystalline cellulose, capsule, (hydroxypropyl methylcellulose), and silica
This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.
If you are pregnant, nursing, trying to conceive, taking any medications, or have a medical condition, please consult your healthcare practitioner before using this product.
Keep out of reach of children.
For optimal storage conditions, store in a cool, dry place. (59°-77°F/15°-25°C) (35-65% relative humidity) Tamper resistant package, do not use if outer seal is missing.